Challenges in Identifying New Antimicrobial Agents Effective for Treating Infections with Acinetobacter baumannii and Pseudomonas aeruginosa

LB Rice - Clinical infectious diseases, 2006 - academic.oup.com
… and enterococcal isolates from infections in patients housed in … Pseudomonas aeruginosa
and Acinetobacter baumannii have developed resistance to multiple antimicrobial agents

Prospects and challenges of developing new agents for tough Gram-negatives

AL Meyer - Current opinion in pharmacology, 2005 - Elsevier
… of Pseudomonas aeruginosa isolates to these same antibiotics … cost of developing a new
antibacterial agent is not justified by the … due to multidrug-resistant Acinetobacter baumannii

Insights into newer antimicrobial agents against Gram-negative bacteria

N Yaneja, H Kaur - Microbiology insights, 2016 - journals.sagepub.com
… discusses the major challenging issues for their management. … Finding suitable antimicrobial
treatment options for MDR A. … Pseudomonas aeruginosa and Acinetobacter baumannii. …

Global Challenge of Multidrug-Resistant Acinetobacter baumannii

F Perez, AM Hujer, KM Hujer, BK Decker… - Antimicrobial agents …, 2007 - Am Soc Microbiol
… but not in Enterobacteriaceae or in Pseudomonas aeruginosa (… baumannii has been identified
and characterized as a … these agents in the treatment of serious Acinetobacter infections

[HTML][HTML] Developing new therapeutic approaches for treating infections caused by multi-drug resistant Acinetobacter baumannii: Acinetobacter baumannii therapeutics

P Gallagher, S Baker - Journal of Infection, 2020 - Elsevier
… , Acinetobacter baumannii, Pseudomonas aeruginosa, and … baumannii infections, there is
mounting pressure to find new … While A.baumannii remains a major public health challenge

Multidrug-resistant Pseudomonas aeruginosa and Acinetobacter baumannii: resistance mechanisms and implications for therapy

AP Zavascki, CG Carvalhaes, RC Picao… - Expert review of anti …, 2010 - Taylor & Francis
… to antimicrobial drugs currently used for the treatment of … baumannii; however, Spanish
researchers have identified … Considering the issues presented previously, we will further discuss …

New Treatment Options against Carbapenem-Resistant Acinetobacter baumannii Infections

B Isler, Y Doi, RA Bonomo… - Antimicrobial agents and …, 2019 - Am Soc Microbiol
… in CRAB infections, including BSI, did not find evidence for … therapy mainly against
Pseudomonas aeruginosa rather than … ) for the treatment of bacterial infections is challenging due …

[HTML][HTML] New Drugs for the Treatment of Pseudomonas aeruginosa Infections with Limited Treatment Options: A Narrative Review

AR Losito, F Raffaelli, P Del Giacomo, M Tumbarello - Antibiotics, 2022 - mdpi.com
… It is intrinsically resistant to many antimicrobial agents and additional acquired … to
ceftolozane-tazobactam has been identified in P. … aeruginosa, in challenging clinical situations …

Novel Strategies for the Treatment of Pseudomonas aeruginosa Infections

…, C Lu, RW Hartmann, M Empting, A Titz - Journal of medicinal …, 2016 - ACS Publications
… points of attack of antibiotic agents comprising the inhibition of … of antimicrobial peptides
have been identified and deposited … , circumventing transport issues of potential drugs with the …

The antimicrobial peptide ZY4 combats multidrug-resistant Pseudomonas aeruginosa and Acinetobacter baumannii infection

J Mwangi, Y Yin, G Wang, M Yang… - Proceedings of the …, 2019 - National Acad Sciences
… These findings identify ZY4 as an ideal candidate against … for new antimicrobial drugs, only
a few new viable antibiotics … Development of resistance is a great challenge that hampers …